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赫斯佩里丁 - 加载的PVA/酸水凝:针对NFκB/iNOS/COX-2/TNF-α炎症信号通路

Ahmad S Kodous^1,2, Mostafa A Abdel-Maksoud³, Mohamed A El-Tayeb³

¹Department of Molecular Oncology, Cancer Institute Women's Indian Association (WIA), Tamilnadu, India.

Frontiers in immunology

|April 30, 2024

概括

这项研究开发了一种新的聚乙烯醇-酸水凝,其中包含hesperidin,用于增强伤口愈合. 含有hesperidin的水凝显示出显著的抗氧化和抗炎性质,加速了愈合过程.

科学领域:

生物材料科学生物材料科学
伤口治愈研究研究伤口治愈研究
药理学药理学是指药理学的学科.

背景情况:

皮肤损伤需要有效的治疗来加速愈合.
是一种类生物黄,它具有抗微生物,抗氧化和抗炎性质,有利于伤口修复.

研究的目的:

为了配制一种聚乙烯醇 - - 酸 (PVA/A) 水凝,将素 (H) 结合起来,以改善伤口愈合.
评估PVA/AH水凝通过其抗氧化和抗炎作用促进伤口愈合的疗效.

主要方法:

通过玛辐射 (30kGy) 进行交联的PVA/A混合膜的制造.
用hesperidin溶液浸膜以控制药物输送.
对细胞毒性,抗氧化活性,自由基清除,抗炎作用和膜稳定性的评估.
评估水凝对BJ-1人类皮肤细胞中氧化应激和炎症标记物的影响.

主要成果:

与PVA/A (49%) 相比,PVA/AH水凝表现出显著的激素清除活性 (87%).
证明了人类红细胞膜血解,低压和蛋白质变性化的高度抑制.
基因表达分析显示抗氧化/抗炎基因增加和TNFα,NFκB,iNOS和COX2的下调分别为67%,52%,58%和60%.

结论:

开发的PVA/AH水凝有效地提供hesperidin,利用其抗氧化和抗炎性质.
这种配方显示出作为伤口愈合的安全和有效策略的承诺.
PVA/AH水凝和玛辐射的组合为Hesperidin在伤口护理中提供了一个新的药物输送平台.

关键词:

生物材料水凝是一种生物材料.马辐射辐射的马辐射辐射.这就是hesperidin.这是一种水凝.伤口上使用了伤口带.伤口愈合伤口愈合

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