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circIARS:一种潜在的血生物标志物,用于诊断非小细胞肺癌

Qi Zhang^1,2,3, Xinfeng Fan^1,2,3, Xinyu Zhang^2,4

¹Medical School of Nantong University, Nantong University, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China.

Acta biochimica et biophysica Sinica

|April 30, 2024

概括

CircIARS是一种循环RNA,在非小细胞肺癌 (NSCLC) 患者中显示出高水平,作为早期诊断和监测的有希望的生物标志物. 它的表达使NSCLC与其他肺部疾病区别开来,并且与疾病进展相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

非小细胞肺癌 (NSCLC) 是全球癌症死亡的主要原因.
早期诊断NSCLC显著提高了患者的生存率.
新型生物标志物对于准确及时检测NSCLC至关重要.

研究的目的:

在NSCLC中识别和描述差异表达的循环RNA (circRNAs).
评估circiARS在NSCLC中的诊断和预后价值.
探索circiARS作为NSCLC辅助诊断和动态监测的潜在生物标志物.

主要方法:

从测序数据中选差异表达的circRNAs.
使用桑格测序,RNase R检测,AGE和FISH进行分子表征.
通过qRT-PCR对circiARS表达的量化和使用ROC曲线分析进行诊断价值评估.
在术后,化疗和复发患者中的血循环分析.

主要成果:

与健康对照人群相比,NSCLC组织和血中circIARS的表达显著更高.
circIARS有效地区分NSCLC与良性肺病 (BPD),小细胞肺癌 (SCLC) 和健康个体.
化学疗法后circiARS水平下降,在复发时增加,表明预后价值.
在ROC分析中,CircIARS的检测效率高于传统标记器.
循环IARS表达与临床病理学参数相关.

结论:

血循环是NSCLC诊断的稳定和特定的生物标志物.
circIARS有助于对NSCLC患者的辅助诊断和动态监测.
对circiARS的下游相互作用 (miRNA,RBP) 进行进一步的研究是有必要的.

关键词:

生物标志物生物标志物一个圆形的圆周.诊断诊断诊断诊断诊断诊断非小细胞肺癌的肺癌.预后预后预后

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