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维生素K抗体治疗期间的遗传多态化和重大出血风险:BLEEDS病例-队列研究

Eleonora Camilleri1, Mira Ghobreyal1, Mettine H A Bos2,3

  • 1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Pharmacotherapy
|April 30, 2024
PubMed
概括

在维生素K对抗剂使用者中,CYP4F2和VKORC1的遗传变异增加了严重出血的风险. 结合这些遗传因素,特别是CYP4F2-TT和VKORC1-AA,显著增加出血风险,建议个性化抗凝药治疗.

关键词:
抗凝固剂是一种抗凝固剂.库马林是一种素.发生出血 发生出血药物遗传学 药物遗传学单个核酸的多态性.

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