利用免疫治疗来实现对HIV-1的功能治疗
Fabrícia Heloisa Cavicchioli Sugiyama1,2,3, Lisa Loksø Dietz2,3, Ole Schmeltz Søgaard2,3
1Department of Clinical, Toxicological and Bromatological Analysis, University of São Paulo, Ribeirão Preto, Brazil.
Current opinion in HIV and AIDS
|April 30, 2024
概括
新的免疫疗法显示出对功能性HIV-1治疗的希望,旨在在没有每日抗逆转录病毒治疗 (ART) 的情况下控制病毒. 虽然挑战仍然存在,但广泛中和抗体 (bNAbs) 对实现持续缓解提供了谨慎的乐观.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 治疗方法 治疗方法
背景情况:
- 抗逆转录病毒疗法 (ART) 改善了HIV-1感染者的预期寿命,但需要终身坚持.
- 开发一种对HIV-1的功能性治疗方法,即免疫系统在没有ART的情况下控制病毒,是主要的研究目标.
研究的目的:
- 审查免疫治疗策略的进展,以实现对HIV-1的功能治疗.
- 评估旨在持续HIV-1缓解的新方法的疗效和安全性.
主要方法:
- 审查最近的临床试验和关于HIV-1免疫疗法的研究.
- 专注于广泛中和抗体 (bNAbs) 和细胞疗法 (T细胞,NK细胞).
- 对增强先天性和适应性免疫力的组合策略的分析.
主要成果:
- 广泛中和抗体 (bNAbs),单独或组合,是持续的HIV-1缓解最有希望的.
- 将T细胞和自然杀伤细胞重定向的细胞疗法显示出令人鼓舞的结果.
- 目前正在进行的试验将bNAbs与其他免疫导向疗法结合起来,以提高免疫力.
结论:
- 免疫疗法通常耐受良好,但在很大程度上未能诱导无ART的HIV-1控制.
- 在使用bNAbs的参与者小组中,有希望的持久的HIV-1控制提供了谨慎的乐观.
- 进一步优化免疫疗法策略可能会导致对HIV-1的功能治疗.
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