在未成年人中比较乙氨基和布洛芬的安全性:基于FAERS数据库
Jing Wang1,2,3, Guowen Feng1,4, Dan Li1,5
1Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
Expert opinion on drug safety
|April 30, 2024
概括
这项研究检查了青少年服用青和布洛芬的不良药物事件 (ADEs). 在儿童中使用乙氨基和布洛芬显示出不同的ADE概况,特别是精神病,肝胆道和/尿道疾病.
科学领域:
- 儿科药理学 儿科药理学
- 药品安全 药品安全
- 不良事件监测不良事件监测
背景情况:
- 在COVID-19期间,非类固醇抗炎药物 (NSAID) 的使用急剧增加.
- 未成年人是脆弱群体,需要仔细评估药物使用情况.
- 了解儿科药物不良事件 (ADEs) 对于安全的药物实践至关重要.
研究的目的:
- 在18岁以下的个体中调查与青和布洛芬使用相关的不良药物事件 (ADEs).
- 在儿科患者群体中确定乙氨基和布洛芬的特定ADE模式.
主要方法:
- 从FDA的不良事件报告系统 (FAERS) 中提取了对 acetamol和ibuprofen的ADE数据.
- 分析了从2014年第一季度到2022年第三季度的数据.
- 专注于不同年龄层的未成年人的ADEs.
主要成果:
- 未成年人吸毒与受伤,中毒和手术并发症有关.
- 青少年使用乙氨基 (12.6%) 和布洛芬 (9.2%) 的精神病障碍较高.
- 乙氨基使用与更多的肝胆道疾病 (10.3%-11.5%) 相关,而布洛芬使用显示脏和尿道疾病的发病率较高 (5.0%-9.6%).
结论:
- 在不同儿科年龄组中,乙氨基和布洛芬表现出明显的ADE特征.
- 儿科临床药剂师可以利用这些发现进行有针对性的药物监测.
- 尽量减少儿童的ADEs需要了解特定年龄的药物事件概况.
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