身体质量指数的高变化与事件心力衰竭独立相关
Chang Liu1, Yiyun Chiang1, Qin Hui1
1Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA.
Journal of the American Heart Association
|April 30, 2024
概括
波动的体重指数 (BMI) 显著增加患心力衰竭 (HF) 的风险. 随着时间的推移跟踪BMI变化对于预测个体中HF发病率至关重要.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 肥胖问题研究研究
背景情况:
- 心力衰竭 (HF) 是一个日益严重的公共卫生问题,患病率和死亡率很高.
- 肥胖是已知的高血压风险因素,最近的证据表明,BMI波动也可能提高心血管风险.
研究的目的:
- 调查身体质量指数 (BMI) 变化与心力衰竭 (HF) 发生率之间的关联.
主要方法:
- 研究人员对99368名来自英国生物银行的白人参与者进行了前性队列研究.
- 参与者内部的BMI变异性使用标准化偏差和变化系数在12.5年的中位数随访期间进行评估.
- 用一个竞争的风险模型 (Fine和Gray) 来分析BMI变化和事件HF之间的关联,并对混因素进行调整.
主要成果:
- 较高的BMI变化,通过SD和变化系数来衡量,显着与HF发病率风险增加有关.
- 对于HF发病率的危险比率随着BMI变化更高而增加 (SD:HR1.05,95%CI1.03-1.08;CV:HR1.07,95%CI1.04-1.10).
结论:
- 纵向健康记录有效捕捉BMI波动.
- 体重指数波动独立预测心力衰竭 (HF) 的发生率.
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