在疼痛的脊椎骨转移的传统放射治疗后脊柱不稳定性的变化
Eiji Nakata1, Shinsuke Sugihara2, Ryuichi Nakahara1
1Department of Orthopedic Surgery, Okayama University Hospital, Okayama, Japan.
Cancer control : journal of the Moffitt Cancer Center
|April 30, 2024
概括
放射治疗有效地减少疼痛,并改善脊柱稳定性在6个月的脊椎转移患者. 脊柱元件的后侧参与 (PLISE) 是治疗后持续脊柱不稳定的关键预测因素.
科学领域:
- 在瘤学瘤学.
- 整形外科 整形外科 整形外科
- 辐射疗法 辐射疗法
背景情况:
- 精确评估脊柱不稳定性对于评估疼痛脊柱转移患者放射治疗 (RT) 的有效性至关重要.
- 脊柱的不稳定性可以显著影响患者的生活质量和治疗结果.
研究的目的:
- 在6个月的时间内,回顾评估RT在治疗脊柱不稳定的有效性.
- 评估疼痛,放射性反应和脊柱不稳定性的变化,使用RT后的脊柱不稳定性新形成评分 (SINS).
主要方法:
- 对108名患有疼痛脊椎转移的患者进行了回顾性评估,这些患者接受了RT治疗.
- 在基线和RT后1,2,3,4和6个月评估机械疼痛,放射性反应和SINS.
- 多变量分析以确定持续脊柱不稳定的风险因素.
主要成果:
- 67%的患者在1个月后观察到疼痛缓解,在RT后6个月后增加到100%.
- 中位数SINS从基线时的8个下降到6个月后的4个,这表明脊柱稳定性有所改善.
- 在1个月后,脊柱元件的后侧涉 (PLISE) 是持续潜在不稳定/不稳定脊柱的唯一预测因素.
结论:
- 放射治疗可以改善疼痛,并促进脊柱稳定性随着时间的推移在脊椎转移的患者.
- 尽管有潜在的脊柱体崩,但重新化有助于恢复脊柱稳定.
- 临床医生应考虑使用PLISE来预测RT后持续的脊柱不稳定性.
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