装有精油的纳米结构脂质载体:对抗SARS-CoV-2的战略
L F Almeida1, G A Gil2, L N Moraes1,3
1Laboratory of Applied Biotechnology, Clinical Hospital of the Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
Journal of microencapsulation
|April 30, 2024
概括
来自Lippia sidoides和Syzygium aromaticum的精油,当被纳米结构脂质载体 (NLC) 封装时,显示出显著的SARS-CoV-2杀毒活性. 这些NLC配方提供了一种有希望的方法来对抗病毒.
科学领域:
- 纳米技术 纳米技术
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于COVID-19的流行,需要新的抗病毒策略.
- 精油 (EOs) 具有已知的抗菌特性.
- 在纳米结构脂质载体 (NLC) 中封装可以提高EO的输送和稳定性.
研究的目的:
- 为了评估Lippia sidoides和Syzygium aromaticum在NLC中封装的EO的SARS-CoV-2杀毒功效.
- 用这些EO装载的阳离子和阴离子NLC的物理化学特性.
- 评估EO类型和NLC成分对杀病毒活性的影响.
主要方法:
- 用Lippia sidoides和Syzygium aromaticum EOs装载的阳离子和阴离子NLC的开发和表征.
- 评估NLC的物理化学性质,包括粒子大小,多分散率指数 (PDI) 和泽塔潜力.
- 在NLC中确定EO的封装效率.
- 通过减少病毒数量来评估SARS-CoV-2病毒杀伤活性.
主要成果:
- NLCs表现出稳定的物理化学特性,颗粒大小在109.30至160.53nm之间,并具有高的泽塔电位.
- 在NLCs中的EO实现了高封装效率 (84.6到100%).
- 装有EO的NLC显示出显著的SARS-CoV-2杀毒活性,与对照组相比,减少了2个日志以上的病毒计数.
结论:
- 在NLC中封装的Lippia sidoides和Syzygium aromaticum EO表现出强大的SARS-CoV-2杀毒效应.
- 尼尔卡为这些精油提供了稳定有效的输送系统.
- 这种基于纳米技术的方法为SARS-CoV-2抑制提供了一个创新的策略.
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