电子烟吸入对电子烟使用者粘膜清除的急性影响
William D Bennett1, Phillip W Clapp1,2,3, Kirby L Zeman1
1Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
与一些预期相反,电子烟的使用可能会提高年轻成年人的粘膜干净度 (MCC). 这种急性效应可能是由于呼吸道液体和粘液分泌量增加,尽管其持续时间尚不清楚.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (EC) 使用与慢性支气管炎症状有关,可能是由于粘膜细胞清除 (MCC) 受损.
- 关于EC吸入对*in vivo*MCC的急性和慢性影响的数据有限.
研究的目的:
- 为了研究受控的电子烟吸入对年轻成年人的 *in vivo* 粘膜干净度的急性影响.
主要方法:
- 在5名年轻成年男性中*in vivo*测量MCC,使用放射性标记的气溶 (Tc99m硫合物).
- 在90分钟内评估整个肺部清除,在前60分钟内定期蒸汽 (总共60口).
- 使用了第四代盒装mod EC与无味电子液体 (3mg/mL尼古丁).
主要成果:
- 与基线相比,在EC挑战期间,周围肺清除显著增加 (24% ±6对12% ±6,p<0.05).
- 这种急性增强与在较高度下尼古丁诱导的眼节拍减缓的研究形成鲜明对比.
结论:
- 急性电子烟挑战似乎在年轻成年人中增强了*in vivo*的MCC.
- 结果表明,支气管表面液体和粘素分泌的短暂增加.
- 需要进一步的研究来了解EC使用对呼吸系统健康的长期影响.
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