HCMV US2 选择了 TRC8 来降解内细胞网膜居住蛋白质 LMAN2L

Leah M Hunter1,2, Joanne Kite1,2, Alice Fletcher-Etherington1,2

  • 1Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

PubMed
概括

人类细胞巨型病毒 (HCMV) 蛋白pUS2降解了像 (LMAN2L) 这样结合2的莱克曼诺,以间接降低细胞表面的整合素α-6 (ITGA6). 这揭示了HCMV免疫逃避的双重机制.

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