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Updated: Jun 27, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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通过四胺-有机催化三组分级联Noevenagel/Michael/循环化序列的spiro[4H-chromene-3,3'-oxindoles]的不对称合成

Liming Wang1, Hongwen Mu1, Yuhong Sun1

  • 1Department of Pharmacy, Jilin Medical University, Jilin, 132013, People's Republic of China.

Molecular diversity
|April 30, 2024
PubMed
概括

这项研究提出了使用一种新的有机催化级联反应的高效非对称合成螺旋氧辛醇衍生物. 该方法实现了良好的产量和高的对有价值的螺旋氧醇化合物的高反选择性.

关键词:
布诺维纳格尔/迈克尔/循环化具有抗选择性的人类选择性.奎尼丁 - 方胺螺旋氧基因醇 (spirooxindoles) 是一种氧基因醇.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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