黄素通过减少细胞亡和氧化应激减轻大脑衰老,从而减轻黄素的作用
Mehran Cheriki1, Masoumeh Habibian2, Seyyed Jafar Moosavi1
1Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran.
Metabolic brain disease
|April 30, 2024
概括
黄素是一种天然抗氧化剂,通过减少氧化应激和脑亡,在老老鼠中表现出神经保护作用. 这种天然化合物增强了来自大脑的神经营养因子 (BDNF) 和血管内皮生长因子 (VEGF) 的水平,表明它对大脑衰老有治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 老年学是指老年学的学科.
背景情况:
- 大脑衰老是一个自然的生理过程.
- 氧化应激和亡是大脑衰老的关键机制.
- 黄素具有已知的抗氧化和神经保护性质.
研究的目的:
- 为了研究黄素对老老鼠大脑衰老的保护作用.
- 评估黄素对氧化应激,亡,BDNF和VEGF的影响.
- 探索黄素对与年龄相关的神经变化的治疗潜力.
主要方法:
- 年龄较大的雌性Wistar大鼠被分为对照组,盐水和黄素治疗组.
- 库尔库 (30 mg/kg) 通过腹腔内给药,每周5天,持续8周.
- 测量结果包括脂质过氧化,BDNF,VEGF,超氧化解突变酶 (SOD) 活性和亡蛋白 (BCl-2,Bax).
主要成果:
- 在老老鼠中,黄素治疗减弱了大脑脂质过氧化.
- 观察到BDNF,VEGF,SOD活动和BCl-2的显著增加.
- 没有注意到巴克斯蛋白水平的显著变化,这表明细胞亡的抑制.
结论:
- 黄素通过减少氧化应激和抑制亡来缓解大脑衰老.
- 黄素上调SOD活动,增强神经营养因子,如BDNF和VEGF.
- 黄素对与大脑衰老,神经发生和血管发生相关的神经疾病具有治疗前景.
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