在中国人口中使用支气管扩展前和后螺旋体测量参考值的影响
Ke Huang1,2, Xueyan Han3, Zhaoyang Pan3
1National Center for Respiratory Diseases, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
American journal of respiratory and critical care medicine
|April 30, 2024
概括
现在,中国成年人的新螺旋计参考值已经可用,区分了支气管扩展前和支气管扩展后的测量. 支气管扩展后的值对于识别更多的空气流量限制和慢性阻塞性肺病患者至关重要.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 流行病学 流行病学
背景情况:
- 螺旋测量对于诊断和管理呼吸道疾病至关重要.
- 对于中国人口来说,需要具有全国代表性的螺旋测量参考方程.
- 支气管扩张前 (BD前) 与支气管扩张后 (BD后) 基准值对中国成年人的影响仍未评估.
研究的目的:
- 为中国成年人建立BD前和BD后的螺旋计参考值.
- 评估疾病流行和严重程度分级的差异,使用BD前与BD后的参考.
- 评估BD后参考值在识别阻塞性肺部疾病中的临床实用性.
主要方法:
- 利用来自中国肺部健康 (CPH) 研究的数据,包括17,969名健康非吸烟者用于参考值计算.
- 计算FEV1,FVC和FEV1/FVC比率的BD前和BD后的参考值.
- 将这些参考值应用于整个CPH队列 (N=50,991),以比较疾病的流行率和严重程度.
主要成果:
- 使用BD前的参考,空气流限制的流行率为5.36%,使用BD后的参考为8.02%.
- 患有BD后FEV1/FVC低于BD后参考值但高于BD前参考值的个体报告了更多的呼吸症状,并表现出较差的螺旋测量.
- 在使用BD后FEV1预测值时,额外发现3.51%的参与者患有II-IV级慢性慢性肺炎.
结论:
- 为代表性中国成年人群生成和应用BD前后的螺旋计参考值.
- 后BD参考值提高了对阻塞性肺部疾病有风险的个体的识别.
- 需要进一步研究后BD参考值的诊断和预后价值.
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