食二碳酸酸提供一种不可储存的替代脂肪来源,可以保护小鼠免受肥胖的影响
Eric S Goetzman1, Bob B Zhang1, Yuxun Zhang1
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
The Journal of clinical investigation
|April 30, 2024
概括
消费二氧酸,如二二氧酸 (DC12) 能促进新陈代谢,减少身体和肝脏的脂肪,并改善葡萄糖耐受性. 这些食脂肪被多种组织利用,为肥胖和代谢障碍治疗提供了潜力.
科学领域:
- 生物化学 生物化学
- 代谢科学 代谢科学
- 营养科学 营养科学
背景情况:
- 二碳酸脂肪酸是通过脂肪酸 ω-氧化在肝脏和脏中产生的.
- 饮食中二糖酸的代谢作用在很大程度上仍未被探索.
研究的目的:
- 在小鼠模型中研究食中的十二碳二氧酸 (DC12),一种12碳二氧酸的代谢作用.
主要方法:
- 在9周的时间里,小鼠吃了一种含有DC12每日卡路里20%的饮食.
- 评估了代谢参数,身体组成和DC12的组织利用.
- 在体外研究中,研究了脂肪组织中的DC12代谢.
主要成果:
- 摄入DC12增加了新陈代谢率,减少了体脂,减少了肝脂,改善了葡萄糖耐受性.
- 在多种组织中检测到DC12分解产物,表明系统利用和避免一次性肝脏代谢.
- DC12通过过氧体 (ACOX1-依赖) 和线粒体途径代谢,而不是通过细胞内存储.
结论:
- 食DC12被各种组织有效利用,并对代谢健康有显著的益处.
- 像DC12这样的二氧酸显示出对抗肥胖和代谢障碍的治疗药物有前途.
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