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Updated: Jun 27, 2025

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瘤抑制剂TMEM127的损失通过破坏膜动态驱动RET介导的转化

Timothy J Walker1, Eduardo Reyes-Alvarez1, Brandy D Hyndman1

  • 1Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada.

eLife
|April 30, 2024
PubMed
概括

丢失TMEM127会导致受体氨酸激酶 (RTK) 在细胞表面积累,从而推动染细胞 (PCC) 细胞的增殖. 这表明TMEM127对于调节细胞表面蛋白贩运和防止癌症信号传递至关重要.

关键词:
在RET的基础上,RET是RET.在TMEM127中,我们可以看到TEMEM127.癌症生物学 癌症生物学细胞生物学 细胞生物学克拉林介导的内细胞分裂人类 人类 人类 人类 人类 人类 人类膜动力学 膜动力学叶染色细胞瘤 ( pheochromocytoma) 是一种致血性细胞瘤.

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