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Updated: Jun 27, 2025

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小酸中枢液中肌缩侧硬化症的小酸指纹

Rea Lumi1, Susanne Petri1, Justyna Siwy2

  • 1Department of Neurology, Hannover University Medical School, Hannover, Germany.

PloS one
|April 30, 2024
PubMed
概括

这项研究确定了肌性侧面硬化症 (ALS) 患者大脑脊髓液 (CSF) 中变化的,包括VGF,骨质,SOD-1和EFEMP1,为ALS病理生理学提供了洞察力. 这些发现可能指导未来的ALS治疗策略.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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