Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Conservation of Small Populations02:04

Conservation of Small Populations

13.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
13.1K
Pedigree Analysis01:35

Pedigree Analysis

84.2K
Overview
84.2K
Frequency-dependent Selection01:21

Frequency-dependent Selection

22.0K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.0K
Punnett Squares01:00

Punnett Squares

114.4K
Overview
114.4K
Conservation of Declining Populations02:07

Conservation of Declining Populations

9.6K
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
9.6K
Chi-square Analysis02:46

Chi-square Analysis

38.2K
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
38.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The effect of age and sex on the rate of germline mutations in barn owls.

Genome biology and evolution·2026
Same author

Genetically diverse populations hold the keys to climatic adaptation in the Western barn owl (Tyto alba).

Communications biology·2026
Same author

Inbreeding depression in morphological and growth traits of wild barn owls (Tyto alba).

Proceedings. Biological sciences·2026
Same author

Allelic association analyses: estimation recommendations.

Genetics·2026
Same author

Benchmarking imputation accuracy in the presence or absence of a reference panel.

Molecular biology and evolution·2026
Same author

Hitchhiking Parasites: Unstructured Populations of Bat Ectoparasites Reveal Host-Driven Dispersal.

Molecular ecology·2026

相关实验视频

Updated: Jun 27, 2025

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
06:44

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

7.6K

在结构化群体中检测内生抑郁症.

Eléonore Lavanchy1,2, Bruce S Weir3, Jérôme Goudet1,2

  • 1Department of Ecology and Evolution, University of Lausanne, Lausanne 1015, Switzerland.

Proceedings of the National Academy of Sciences of the United States of America
|April 30, 2024
PubMed
概括

量化亲生繁殖抑郁症至关重要. 线性混合模型 (LMMs) 具有特定的遗传亲属关系矩阵 (GRMs) 和近亲繁殖系数可以提高准确性,特别是在结构化种群中.

关键词:
亲生繁殖是一种亲生繁殖.亲生关系导致的抑郁症.人口结构 人口结构.

更多相关视频

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
08:39

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing

Published on: September 1, 2017

7.6K
Mass-Rearing and Molecular Studies in Tortricidae Pest Insects
06:22

Mass-Rearing and Molecular Studies in Tortricidae Pest Insects

Published on: March 25, 2022

2.7K

相关实验视频

Last Updated: Jun 27, 2025

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
06:44

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

7.6K
Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
08:39

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing

Published on: September 1, 2017

7.6K
Mass-Rearing and Molecular Studies in Tortricidae Pest Insects
06:22

Mass-Rearing and Molecular Studies in Tortricidae Pest Insects

Published on: March 25, 2022

2.7K

科学领域:

  • 人口遗传学 人口遗传学
  • 量化遗传学 量化遗传学
  • 保护生物学 保护生物学
  • 人类遗传学 人类遗传学

背景情况:

  • 亲生繁殖及其对健康的影响在遗传学和保护方面至关重要.
  • 目前用于量化近亲繁殖及其影响的方法缺乏共识.
  • 准确的估计对于理解遗传健康和物种生存至关重要.

研究的目的:

  • 为了比较各种近亲繁殖系数和统计模型来估计近亲繁殖抑郁症.
  • 用模拟和真实的人类基因组数据评估方法性能.
  • 为不同的人口结构确定最佳方法.

主要方法:

  • 从血统和全基因组序列 (1000个基因组项目) 中模拟的特征.
  • 比较的近亲繁殖系数:等位基因共享,结合性子细胞的相关性 (加权/未加权),以及身份-按-血统段.
  • 与不同的遗传关系矩阵 (GRMs) 的线性模型 (LM) 和线性混合模型 (LMM) 进行比较.

主要成果:

  • 线性混合模型 (LMMs) 在结构化群体中表现优于标准线性模型.
  • 最佳的LMM性能需要为同胞繁殖系数的结合性子细胞提供加权的相关性.
  • 基于基因共享的GRM在结构化数据的LMM中最有效.

结论:

  • LMMs为亲生繁殖抑郁症估计提供了更强大的框架,特别是在人口结构方面.
  • 选择亲生生殖系数和GRM显著影响结构化种群的准确性.
  • 推方法增强了保护和人类遗传学研究的遗传洞察力.