精神分裂症患者的状功能性低连接性 遭受负面症状的精神分裂症患者,纵向发现
Tal Geffen1, Samyogita Hardikar2, Jonathan Smallwood3
1Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center (NCRC), Campus Mitte, Berlin, Germany.
Schizophrenia bulletin
|April 30, 2024
概括
研究人员确定了与精神分裂症 (SZ) 的负面症状相关的特定大脑连接模式. 感觉运动条纹体和上额叶之间较弱的连接可能成为这些衰弱症状的稳定生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 认知神经科学 认知神经科学
背景情况:
- 精神分裂症 (SZ) 的负面症状,包括冷漠和表达能力下降,显著损害生活质量,缺乏有效的治疗方法.
- 条形体的功能划分 (边缘激励,关联认知,感官运动感官) 为识别生物标志物提供了潜在的目标.
- 这项研究调查了与负面症状相关的条状功能连接.
研究的目的:
- 为了确定精神分裂症 (SZ) 中负面症状的潜在神经影像生物标志物.
- 检查精神分裂症 (PwSZ) 患者的条纹体中稳定的纵向功能连接差异.
- 为了将条纹连接与负面症状和认知功能相关联.
主要方法:
- 纵向,双中心静止状态fMRI (rsfMRI) 研究.
- 在77名精神分裂症患者 (PwSZ) 和66名对照患者中,对条状细胞种子与全脑功能连接的分析.
- 稳定的群体差异的类内相关性,从连接性预测症状,反之亦然.
主要成果:
- 在PwSZ中,在3个月内确定了稳定的传感运动条体和关联条体的低连接性.
- 发现双边关联性条纹体和圈/前带皮层之间的低连接性.
- 较弱的感觉运动条纹体连接与上额叶相对应的表达减少和预测未来的症状严重程度.
结论:
- 较弱的感觉运动条纹体和上顶叶片连接性是精神分裂症负面症状的稳定生物标志物.
- 这种连接模式符合生物标志物标准:临床意义,反映了病理生理学,并且在时间和中心之间稳定.
- 这些发现突出了感觉运动条纹体在负面症状中的作用,并为干预提供了潜在的目标.
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