定义长期COVID的亚型和长期疾病的危险因素:基于人口的病例交叉研究
Skyler Resendez1, Steven H Brown2, Hugo Sebastian Ruiz Ayala1
1Department of Biomedical Informatics, University at Buffalo, State University of New York, Buffalo, NY, United States.
JMIR public health and surveillance
|April 30, 2024
概括
长期COVID (COVID-19后的情况) 的新定义确定了323个诊断代码. 这种可行的定义有助于查和管理长期COVID并发症患者.
科学领域:
- 医疗信息学 医疗信息学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球超过7.72亿个COVID-19病例增加了长期COVID (COVID-19后的疾病) 的流行.
- 长期的COVID会带来改变生活的并发症,如慢性疲劳,脑雾和心律失常.
- 制定可行的病例定义对于管理长期COVID的公共卫生影响至关重要.
研究的目的:
- 通过显著增加的迹象,症状和诊断来得出可行的长期COVID病例定义.
- 支持与流行病相关的临床,公共卫生,研究和政策倡议,并提供标准化的定义.
主要方法:
- 一个基于人群的案例交叉研究利用了从2020年1月到2022年8月的退伍军人事务电子健康记录 (ICD-10-CM数据).
- 对比ICD-10-CM代码分配1-7个月后COVID-19阳性测试与367,148个人的前阳性测试数据.
- 根据新病例频率≥1:1000和COVID-19后显著增加的定义长期COVID迹象/症状/诊断.
主要成果:
- 开发了一个长COVID定义,包括143个功能组的323个ICD-10-CM代码,在COVID-19后显著增加.
- 确定了17种医疗专业长期COVID亚型,包括心脏病学.
- 长期COVID患者年龄较大 (8岁),患有更多的并发病 (Elixhauser得分7.97比4.21),并经历了更严重的初始COVID-19 (较低的氧和).
结论:
- 一个可操作的,数据驱动的长COVID定义可以促进临床查,诊断和治疗计划的录取.
- 这个定义支持长期COVID的公共卫生,研究和政策努力.
- 优先监测老年患者,COVID-19期间氧和度低的人,以及长期COVID发展多种并发症的人.
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