在日常纤维肌痛疼痛中的nocebo过敏症和其他预期相关因素:结合实验和电子日记方法
Merve Karacaoglu1, Kaya J Peerdeman1, Julian D Karch2
1Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands; Center for Interdisciplinary Placebo Studies Leiden, Leiden University, The Netherlands.
Journal of psychosomatic research
|April 30, 2024
概括
自我报告的疼痛预期和灾难性,而不是实验室诱导的nocebo过敏症,预测每日纤维肌痛疼痛波动. 针对这些负面预期可能会改善纤维肌痛患者的疼痛管理.
科学领域:
- 疼痛研究 疼痛研究
- 纤维肌痛研究的研究.
- 慢性疼痛中的心理因素
背景情况:
- 期望显著影响疼痛感知.
- 不同预期类型对每日纤维肌痛疼痛波动的具体贡献尚未得到充分理解.
- 诺塞博 (nocebo) 过敏症 (实验诱导的负面期望) 和自我报告的因素需要在纤维肌痛中进行调查.
研究的目的:
- 调查实验衍生的nocebo过敏症与日记评估的预期寿命相关因素之间的关联.
- 确定这些预期因素与纤维肌痛每日疼痛波动之间的关系.
- 为了比较实验与自我报告的预期对日常疼痛的预测能力.
主要方法:
- 41名女性纤维肌痛患者参与了这项研究.
- 在实验室环境中测量了nocebo过敏症.
- 电子日记评估了疼痛预期,焦虑,乐观,疼痛灾难化和疼痛强度,每天三次,持续三周.
主要成果:
- 实验诱导的nocebo过敏症与日记评估的期望没有相关性,也没有预测每日纤维肌痛疼痛.
- 较高的自我报告疼痛预期和疼痛灾难性的预测显著增加了时刻的疼痛增加.
- 在这项研究中,焦虑和乐观程度并不能预测每日疼痛波动.
结论:
- 自我报告的疼痛预期和灾难化对于预测日常纤维肌痛疼痛比实验诱导的nocebo过敏症更相关.
- 需要进一步的研究来将实验性nocebo发现转化为生态瞬间评估 (EMA) 研究.
- 针对减少疼痛预期和灾难性的干预措施,如认知行为疗法 (CBT),可以改善纤维肌痛的日常疼痛管理.
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