神经外科神经调节疗法用于精神疾病
Manish Ranjan1, James J Mahoney2, Ali R Rezai3
1Department of Neurosurgery, WVU Rockefeller Neuroscience Institute, Morgantown, WV, USA.
概括
深度大脑刺激 (DBS) 和其他神经外科神经调节疗法对强迫症 (OCD) 等治疗不耐治疗的精神疾病有前途. 这些先进的治疗方法在传统疗法失败的地方提供了新的希望.
科学领域:
- 神经外科 神经外科
- 精神病学是一个精神病学.
- 神经调节是一种神经调节.
背景情况:
- 精神疾病是全球主要的健康挑战,许多患者对现有治疗没有反应.
- 深度大脑刺激 (DBS) 在运动障碍方面取得了成功,目前正在为精神疾病探索.
- 强迫症 (OCD) 是FDA批准的DBS的唯一精神病学适应症.
研究的目的:
- 审查DBS和其他神经外科神经调节技术对强迫症和其他精神疾病的现状.
- 引入MR引导的聚焦超声波 (MRgFUS) 作为一种新的非侵入性神经调节方法.
主要方法:
- 对精神疾病的DBS现有文献的综述.
- 检查早期发现和MR引导聚焦超声波 (MRgFUS) 的潜力.
主要成果:
- 对精神疾病的DBS研究是有希望的,但需要更大的,受控的试验.
- MRgFUS提供了一种非侵入性的方法来准深层大脑结构,类似于DBS.
- 神经外科神经调节,包括MRgFUS,在精神病学应用中显示出令人鼓舞的早期结果,尽管仍在研究中.
结论:
- DBS和神经刺激 (VNS) 是FDA批准的针对特定精神疾病 (分别是强迫症和抑郁症) 的唯一神经外科神经调节选择.
- 需要进一步的研究来确定这些试验性疗法的疗效和安全性.
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