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土壤有机碳的微生物介导的转化共同调节了抗生素耐药性的演变

Dandan Zhang¹, Houyu Li², Qifan Yang²

¹Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China; College of Resources and Environment, Jilin Agricultural University, Changchun 130118, China.

Journal of hazardous materials

|April 30, 2024

概括

土壤有机碳 (SOC) 矿化驱动了细菌中抗生素耐药性基因 (ARG) 的进化. 关键的代谢途径和微生物进化策略参与了这种共同调节,影响了多药性耐药性.

科学领域:

环境微生物学环境微生物学
分子生物学分子生物学
土壤科学土壤科学

背景情况:

土壤有机碳 (SOC) 影响抗生素耐药性基因 (ARG).
SOC与抗生素耐药性演变相互作用的机制尚不清楚.

研究的目的:

在SOC矿化过程中检查ARG变异.
探索ARG共同进化的微生物机制和代谢途径.
研究OC输入和微生物适应之间的联系.

主要方法:

SOC矿化率与ARG丰度之间的相关性分析.
竞争对手 (压力) 进化战略模型的应用.
进行元基因组和转录基因组分析以确定代谢途径.
关键功能基因的基因删除验证试验.

主要成果:

SOC矿化率与ARG丰度正相关 (p < 0.05).
高OC矿化增加了多重药物耐药性基因 (例如,多重药物_传送器,mexB).
微生物进化转向高耐药性和强适应性,并增加了OC输入.
被确定为关键的共同调节的酸盐到酸盐转化途径.
基因ackA和pta调节了万科米和多药物耐药性的发展.

结论:

SOC矿化是土壤细菌抗生素耐药性演变的关键驱动因素.
特定的代谢途径 (酸盐到酸盐) 和基因 (ackA,pta) 对于这种共同调节至关重要.
了解这些机制为管理土壤生态系统中抗生素耐药性的演变提供了一个框架.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.进化进化进化进化进化进化进化微生物社区的微生物社区.有机碳矿化有机碳矿化土壤土壤土壤.

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