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Updated: Jun 27, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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在血液性恶性瘤中,GPATCH8调节突变SF3B1的错误拼接和致病性

Salima Benbarche1, Jose Mario Bello Pineda2, Laura Baquero Galvis3

  • 1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Molecular cell
|April 30, 2024
PubMed
概括

SF3B1中的突变通过改变RNA拼接而导致癌症. 研究人员确定GPATCH8是这种错误拼接的关键因素,并且使其保持沉默改善了癌症模型,提供了潜在的治疗策略.

关键词:
DHX15 DHX15 的时间.G-补丁域名域名在GPATCH8中使用.这是一个RNARNARNARNARNA.在SF3B1中.在 SUGP1 中,这种白血病是白血病.骨髓发育不良综合征拼接 拼接 拼接 拼接

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells10:06

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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