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活跃吸烟者中CSF中的代谢激素和微量元素的变化表明大脑细胞的氧化损伤
Peiwen Zheng1, Fan Wang2, Hui Li3
1School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China.
Endocrine connections
|April 30, 2024
概括
吸烟会改变大脑中的激素,导致体重增加. 这项研究将吸烟者的更高体重指数与脑脊液 (CSF) 中纤维细胞生长因子21 (FGF21),和铁的水平变化联系在一起.
科学领域:
- 神经内分泌学神经内分泌学
- 代谢研究的研究.
- 毒理学 毒理学 毒理学
背景情况:
- 吸烟与体重变化有关,但潜在的神经生物学机制尚不清楚.
- 脑脊液 (CSF) 中的代谢激素在调节能量平衡和体重方面发挥着至关重要的作用.
- 了解吸烟对这些激素的影响对于解决吸烟相关的健康后果至关重要.
研究的目的:
- 研究CSF中的代谢激素与成年男性吸烟者的体重增加之间的关系.
- 探索可能的神经毒性机制,将吸烟与体重改变联系起来.
主要方法:
- 分析了156名成年男性 (吸烟者和非吸烟者).
- 测量了CSF中的代谢性激素 (adiponectin,FGF21,ghrelin,leptin,orexin A) 和微量元素 (铁,) 的水平.
- 评估了身体质量指数 (BMI) 和血脂质配置文件.
主要成果:
- 与非吸烟者相比,活跃吸烟者表现出更高的BMI,较高的CSFFFGF21,和铁.
- 吸烟者表现出脑流中平素,胆固醇,丁和素A的水平下降.
- 在吸烟者中,CSF FGF21和水平与格林负相关,CSF铁与烟素A相关.
结论:
- 吸烟引起的体重增加与神经毒性影响有关,神经元合成关键代谢激素.
- 神经元中的线粒体功能和氧化应激的破坏可能是这些变化的基础.
- 改变的CSF荷尔蒙配置文件可以了解与吸烟相关的体重增加的神经生物学基础.
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