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甲状腺自身免疫在euthyroid孕妇与更慢的生产性语言学习有关:奥登斯儿童队列研究
Kamilla R Riis1,2, Steen J Bonnema1,2, Anja F Dreyer1,2
1Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
European thyroid journal
|April 30, 2024
概括
怀孕早期母亲甲状腺自身免疫,甲状腺过氧化酶抗体 (TPOAb) 表示,与儿童语言发育延迟有关. 无论母亲的甲状腺激素水平如何,都观察到这种效应,这表明自身免疫本身会影响胎儿的神经发育.
科学领域:
- 生殖医学 生殖医学
- 发育神经科学的发展神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 怀孕期间母亲的甲状腺健康对胎儿发育至关重要.
- 甲状腺自身免疫和功能可能会影响神经发育轨迹.
- 早期怀孕标志物需要对其对后代的长期影响进行调查.
研究的目的:
- 检查母亲甲状腺自身免疫和早期怀孕中的功能以及后代语言学习之间的关联.
- 根据母亲的甲状腺状况,评估12-36个月龄的儿童的语言发展.
- 区分甲状腺自身免疫与甲状腺激素水平对儿童语言发育的影响.
主要方法:
- 一项前性队列研究,包括735个母婴双.
- 孕妇甲状腺过氧化酶抗体 (TPOAb),自由甲状腺素 (FT4) 和甲状腺素在怀孕早期 (中位妊娠12周) 测量.
- 使用MacArthur-Bates沟通发展库存 (MB-CDI) 来评估后代的生产词汇,从12到36个月;使用后勤增长曲线模型.
主要成果:
- 孕产妇TPOAb阳性 (≥11kIU/L) 与女孩 (18-36个月) 和男孩 (33-36个月) 发言的可能性较低有关.
- 低于正常的母体FT4水平显示,与高正常水平相比,女孩和男孩的词汇获取趋势更好.
- 关联被调整为母婴因素; 甲状腺激素的结果是模两可的.
结论:
- 怀孕早期的母体甲状腺自身免疫性会对女孩和男孩的语言学习产生负面影响.
- 观察到的自身免疫对语言发育的影响并不能通过改变母亲的甲状腺功能 (FT4水平) 来解释.
- 独立于甲状腺激素水平的母体甲状腺自身免疫,可能直接影响胎儿的神经发育.
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