发酵启发的宏和坚固的凝/酸水凝用于加速感染伤口愈合
Jing Cheng1, Rixuan Wang1, Yanyu Hu1
1College of Chemical Engineering & College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
International journal of biological macromolecules
|April 30, 2024
概括
这项研究使用微生物发酵和协同硬化开发了一种宏且坚固的凝/酸水凝. 先进的水凝敷料显示出优越的伤口愈合特性,包括抗菌和抗氧化作用.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 再生医学是一种再生医学.
背景情况:
- 凝和酸盐 (SA) 水凝具有生物相容性,但存在质量传输不良,孔隙性较低和机械不稳定性.
- 这些局限性限制了它们的治疗效果和应用范围,特别是在先进的伤口护理中.
研究的目的:
- 为创伤愈合应用开发一种具有巨孔性和坚固性水凝敷料,具有增强性质.
- 研究微生物发酵和协同硬化对水凝特性的影响.
主要方法:
- 使用微生物发酵和协同硬化策略制备一个宏的水凝.
- 制造一个双交联网络水凝 (CaCl2物理和EDC/NHS共价交联).
- 水凝多孔性的特征,胀,机械性能,以及体外/体内表现.
主要成果:
- 开发出来的水凝呈现出一个层次的宏孔结构 (100-500μm),高孔度和优异的膨胀率 (1541.0%).
- 双交叉连接的水凝显示了显著改善的机械性能和回收效率.
- 与无孔的对应物相比,用Ag+处理的水凝敷料显示出增强的生物相容性,抗菌活性,抗氧化特性,以及在体内加速伤口愈合.
结论:
- 这种新的基于凝/SA的巨孔和坚固的水凝敷料为伤口愈合提供了卓越的性能.
- 微生物发酵和协同硬化的结合有效地解决了传统水凝的局限性.
- 这种先进的水凝包装具有在伤口管理中的临床应用的巨大潜力.
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