人体肠道中高度保存的双杆菌:Bifidobacterium longum亚种. 作为一个潜在的老年人天生的免疫力调节器的长
G Longhi1, G A Lugli1, M G Bianchi2,3
1Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, 9370University of Parma, Parco Area delle Scienze 11a, 43124 Parma, Italy.
Beneficial microbes
|April 30, 2024
概括
双细菌长子物种 双菌长子物种 长,在婴儿和百岁以上的人中普遍存在,显示出潜在的抗衰老作用. 这种肠道细菌可以减少炎症,在衰老期间支持宿主健康.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 衰老涉及生理和免疫学衰退,增加脆弱性和疾病易感性.
- 肠道微生物群在整个生命中与宿主相互作用,影响健康.
- 与年龄相关的变化可能会扰乱肠道微生物群.
研究的目的:
- 为了研究肠道相关的双菌在衰老中的作用.
- 为了确定特定的Bifidobacterium longum亚种. 与健康的老年人相关的长菌株.
- 探索这些菌株对宿主免疫反应的分子效应.
主要方法:
- 在肠道微生物群的分析,从出生到老年.
- 基因组重建和Bifidobacterium longum亚种的菌株追踪. 长 (英语:longum) 是指一个长.
- 培养组学用于隔离特定的细菌菌株.
- 在体外微生物与宿主相互作用研究使用转录学.
主要成果:
- 双细菌长子物种 双菌长子物种 长菌被确定为最常见的双菌,特别是在婴儿和百岁以上的人群中.
- 这种B. longum亚种的原型. 在健康的老年人肠道微生物群中发现了长.
- 孤立的B. longum亚种. 长菌株调节宿主免疫系统的转录组,减少与炎症相关的基因表达.
结论:
- 与老年人相关的Bifidobacterium longum亚种. 长原型显示出潜在的抗衰老特性.
- 这些发现表明,特定的肠道细菌在缓解与年龄相关的免疫衰退方面发挥了作用.
- 对B. longum亚种进行进一步的研究. 长期研究可能会导致促进健康衰老的新策略.
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