在胃肠道癌症患者中进行化疗和COVID-19疫苗接种
Mitsukuni Suenaga1, Shinichi Yamauchi2, Ryo Morikawa3
1Department of Clinical Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; m.suenaga1972@gmail.com.
In vivo (Athens, Greece)
|April 30, 2024
概括
对于正在接受化疗的胃肠癌患者,COVID-19疫苗接种是安全有效的. 与疫苗相关的副作用是可以管理的,对治疗计划的影响最小,确保了护理的连续性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 癌症患者需要接种COVID-19疫苗才能继续治疗.
- 在癌症患者中调查COVID-19疫苗的安全性和有效性至关重要.
- 在化疗需要评估期间最佳的疫苗接种时间.
研究的目的:
- 评估COVID-19疫苗接种在胃肠道癌症患者中的安全性和有效性.
- 为了确定化疗期间COVID-19疫苗接种的最佳时间.
- 评估与疫苗相关的不良事件及其对癌症治疗的影响.
主要方法:
- 131名胃肠道癌症患者接受了两剂COVID-19疫苗.
- 研究了两个队列:有79人接受化疗,52人接受手术后.
- 通过采访和自我报告监测不良事件.
主要成果:
- 78.4%的化疗患者在剂量1后经历了副作用,在剂量2后发烧/疲劳增加.
- 53.8%的对照组在第一剂后出现了副作用,在第二剂后出现了71.2%.
- 12名患者 (24.5%) 改变了治疗计划;3人因病情进展而停止治疗.
结论:
- 对于接受化疗的胃肠癌患者来说,COVID-19疫苗接种是安全的.
- 与疫苗相关的不良事件是可以管理的,并且不会显著地扰乱治疗.
- 疫苗接种可以有效地纳入癌症治疗方案.
相关概念视频
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:30Cancer Vaccines
359
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
359
01:27Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
160
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
160
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
198
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
198