在患有结肠直肠癌的患者中,卡佩西他加氧沙治疗诱导的血小板的危险因素
Nanami Kato1, Tsuyoshi Nakai2, Sachiyo Kodama3
1Department of Hospital Pharmacy, Nagoya University Hospital, Nagoya, Japan.
In vivo (Athens, Greece)
|April 30, 2024
概括
低基线白蛋白和血小板计数预测结肠直肠癌患者接受卡佩奇他加氧沙 (CapeOX) 化疗时的血小板缺血. 这些因素可以帮助识别患有这种不良事件风险的患者.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 开普西他加氧沙 (CapeOX) 是用于结直肠癌 (CRC) 的标准辅助化疗.
- 奥克沙利普拉丁诱导的血小板缺血是一种已知的副作用,但风险因素尚未确定.
- 鉴定血小板缺血的预测因素对于治疗CapeOX治疗的CRC患者的管理至关重要.
研究的目的:
- 为了研究CapeOX.X.治疗的CRC患者中血小板缺血的危险因素.
- 在CapeOX治疗期间评估血小板数和非侵入性肝纤维化指数 (APRI,FIB-4) 的变化.
- 为了确定发展血小板缺血的基线预测因子.
主要方法:
- 在七家医院对89名高风险II/III期CRC患者进行了回顾性研究,这些患者接受了CapeOX治疗.
- 对患者人口统计,实验室数据,药物和CapeOX治疗细节的分析.
- 接收器操作特征 (ROC) 分析以确定血小板计数,APRI和FIB-4的切断值.
主要成果:
- 在CapeOX治疗期间,44名患者 (49.4%) 发生了血栓塞缩症.
- 血小板缺血组显示血小板数量减少和APRI/FIB-4分数增加.
- 基线白蛋白≤3.5g/dl和血小板数≤238×10^3/μl是≥2度血小板缺血的独立预测因素.
结论:
- 基线白蛋白水平和血小板计数是CapeOX治疗的CRC患者中血小板缺血的有价值预测指标.
- 这些发现可以有助于早期风险分层和化疗诱导的血小板缺血症的管理.
- 需要进一步的前性研究来验证这些预测因素.
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