利津通过调节mTOR通路来调节风湿性关节炎的老鼠的突性增生和炎症
Liuyu Wang1, Xiangkun Wu2, Quanhui Wan2
1Department of Orthopedics, Nanyang Second General Hospital, Nanyang, P.R. China liuyuwang43@gmail.com.
In vivo (Athens, Greece)
|April 30, 2024
概括
利津是一种天然化合物,通过减少大鼠的炎症和关节损伤,显示出预防和治疗类风湿性关节炎 (RA) 的潜力. 它调节AKT/PI3K/mTOR通路中的关键蛋白质,为RA管理提供了一个有前途的治疗途径.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 风湿性关节炎 (RA) 是一种具有挑战性的自身免疫性疾病,其特征是慢性炎症.
- 目前的RA治疗策略存在局限性,需要新的治疗方法.
研究的目的:
- 研究弗洛里津在鼠类RA模型中的潜在预防和治疗效果.
- 阐明弗洛里津在炎症和关节病理上的作用背后的分子机制.
主要方法:
- 在Wistar大鼠中使用牛II型原蛋白和弗洛恩德的不完整辅助剂诱导了RA.
- 施用了利津治疗,并评估了其对炎症,细胞因子水平和蛋白质表达的影响.
- 在纤维细胞样同胞细胞 (FLS) 的体外研究评估了弗洛里津对增殖,亡以及拉巴氨酸激酶 (mTOR) 途径的机械性标的影响.
主要成果:
- 利津减轻了RA老鼠的炎症和改善了体重管理.
- 利津降低了炎症性细胞因子,并降低了关节组织中AKT,PI3K和mTOR蛋白的表达.
- 在体外,利津降低了TNF-α刺激的FLS的扩散,而不会诱导亡,同时也降低了AKT,PI3K和mTOR表达的调节.
结论:
- 利津在类风湿性关节炎中显示出显著的抗炎和保护作用,防止关节损伤.
- 弗洛里津的治疗效果是通过对AKT/PI3K/mTOR信号通路的调节来实现的.
- 利津为RA治疗提供了一个有前途的天然化合物,影响系统性炎症和局部关节病理.
相关概念视频
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
MAPK Signaling Cascades
5.5K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.5K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K


