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在积极监测的前列腺癌中加入有利的中间风险男性的瘤结局

Pietro Pepe¹, Ludovica Pepe², Michele Pennisi²

¹Urology Unit, Cannizzaro Hospital, Catania, Italy; piepepe@hotmail.com.

In vivo (Athens, Greece)

|April 30, 2024

概括

在积极监测 (AS) 下,中等风险前列腺癌 (PCa) 的男性表现出良好的长期结果. 先进的成像和活检有助于最大限度地降低PCa的AS再分类风险.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
放射学放射学是一门学科.

背景情况:

中期风险前列腺癌 (PCa) 管理通常涉及积极监测 (AS).
在有利的格里森分数3+4/ISUP等级组2 (GG2) PCa中定义AS的最佳标准至关重要.
对于AS的GG2PCa男性的长期瘤结果需要进一步评估.

研究的目的:

评估与AS治疗的中等风险PCa (GG2) 的男性的长期瘤结果.
评估确认活检和高级成像在AS期间风险分层的有效性.
为了确定AS在这个队列中的重新分类和延续率.

主要方法:

从2015年4月到2022年12月,有30名符合特定标准的GG2 PCa男性被纳入AS.
在诊断后12个月进行了确认性跨上和活检 (SPBx) 和多参数核磁共振成像 (mpMRI).
68Ga-PSMA PET/CT被用于对可疑病变的向活检的随访 (PIRADS ≥3或SUVmax >5).

主要成果:

10% (3/30) 患有 GG2 PCa 的男性在初始确认活检时被重新分类.
在平均5.2年的随访期间,只有7.4% (2/27) 的男性被重新分类.
显著的大多数,76.6% (23/30),继续AS没有疾病进展.

结论:

与AS管理的有利GG2前列腺癌的男性表现出有利的长期瘤结果.
对SPBx,mpMRI和PSMA PET/CT的战略性使用有效地降低了AS重新分类的风险.
这些发现支持AS在选择中等风险PCa患者的选择性监测中的作用.

关键词:

积极监视活动的积极监视.中间风险是Pcaca.前列腺癌是前列腺癌.

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