结构性神经可塑性 唱歌在慢性失言症中的影响
Aleksi J Sihvonen1,2,3, Anni Pitkäniemi4, Sini-Tuuli Siponkoski4
1Cognitive Brain Research Unit and Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland aleksi.sihvonen@helsinki.fi.
eNeuro
|April 30, 2024
概括
团体唱歌疗法可以增强慢性失言症患者的大脑结构. 在语言区域和途径中的这种神经可塑性与中风后改善的语音产生和命名能力相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音和语言治疗治疗
背景情况:
- 基于歌唱的干预措施有望改善阿法西亚的语言结果.
- 特定的神经机制,特别是结构性神经可塑性,是中风后失语症中群体歌唱的基础,仍然在很大程度上未被探索.
研究的目的:
- 为了研究与慢性失语症中基于小组的歌唱干预相关的大脑结构性神经可塑性变化.
- 确定这些神经可塑性变化是否与语言功能的改善相关,特别是命名和重复.
主要方法:
- 一项为期4个月的随机对照试验,涉及28名患有慢性中风后失语症的患者.
- 干预组接受了多组合歌唱疗法;对照组接受了标准护理.
- 结构神经成像 (T1加权的MRI,扩散加权的MRI) 和行为语言评估 (西方失语电池) 在基线和5个月后进行.
主要成果:
- 与对照组相比,唱歌组在关键语言路径中表现出增强的白质连接性,包括左侧弧形囊 (AF) 和前部植入管 (FAT),与对照组相比.
- 在唱歌组中,灰质体积在左下额叶皮层 (布罗德曼区域44) 增加.
- 左侧BA44,AF和FAT中的神经可塑性与命名能力的改善显著相关.
结论:
- 基于群体的唱歌干预可以诱导严重的结构性神经可塑性在左半球语言区域和双边语言途径在慢性失语患者.
- 这些结构性大脑变化与语音生产的功能性改善有关,特别是命名.
- 歌唱疗法提供了一种可行的方法,可以促进脑部的恢复,并增强中风后的语言功能.
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