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缺陷的食管胃结放松和肺移植的结果

Andrés R Latorre-Rodríguez^1,2, Madison Golla¹, Ashwini Arjuna^1,3

¹Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

|April 30, 2024

概括

肺移植受体 (LTRs) 中常见的升高的综合放松压力 (IRP),但通常在手术后恢复正常. 持续高的IRP可能与更好的长期生存相关,尽管其他结果仍然相似.

科学领域:

胃肠病学胃肠病学
肺部病理学肺部病理学
移植手术移植手术

背景情况:

缺陷的食管胃节放松,包括食管胃节外流阻塞和,在肺移植接受者 (LTRs) 中了解得很少.
在肺移植 (LTx) 之前,高集成放松压 (IRP) 的临床意义需要进一步研究.

研究的目的:

为了确定在LTR中高高的术前IRP的患病率.
根据术后IRP正常化,评估临床结果,包括存活率和慢性肺异位移植功能障碍 (CLAD) 无存活率,在LTR中.

主要方法:

在2019年1月至2022年8月期间接受LTx的LTR的回顾性审查.
对术前和术后IRP的高分辨率测量数据的分析.
使用卡普兰-梅尔曲线和常规化IRP (N-IRP) 和持久高IRP (PH-IRP) 组之间的日志等级测试,比较整体生存率和无CLAD生存率.

主要成果:

在352名LTR中,有44人 (12.5%) 患有术前IRP升高 (>15 mmHg).
37名LTR患者可进行术后测量;24名 (64.9%) 患者的IRP正常化.
与PH-IRP组 (92.3%) (P=0.086) 相比,N-IRP组 (77.2%) 的两年整体存活率趋向于较低.
没有CLAD的生存率,初级移植功能障碍和急性细胞排斥率在各组之间相似.

结论:

在LTx候选人中,术前IRP升高是相对常见的,在移植后经常恢复正常.
在LTx后持续升高的IRP可能与改善长期存活的趋势有关,而不会影响其他关键临床结果.

关键词:

食道机动性的食道机动性消化管胃结口的结口高分辨率的高分辨率计量仪.肺部移植肺部移植

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