基于三酸/β-三酸/无水酸/基甲基纤维素的新型自设水泥:从水化机制到生物评估
Meng Wu1, Laijun Xu2, Fei Xing3
1School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, PR China.
International journal of biological macromolecules
|April 30, 2024
概括
一种新的可注射的三酸 (TCS) 混凝土与β-三酸/单酸无水 (β-TCP/MCPA) 提供了更好的处理,快速设置,并为内牙治疗提供了出色的生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 牙周内科医院 牙周内科医院 牙周内科医院
背景情况:
- 基于三酸盐 (TCS) 的材料在内牙科中取得了临床成功.
- 限制包括处理不善,防洗性能和设置时间缓慢.
研究的目的:
- 开发一种可注射,快速定位的TCS水泥,其中包括基甲基纤维素 (HPMC) 和β-三酸/无水酸 (β-TCP/MCPA).
- 评估新水泥的物理化学性质,水化机制,细胞相容性和骨质/骨质产生潜力.
主要方法:
- 开发了一个可注射的快速设置TCS/β-TCP/MCPA水泥与HPMC.
- 进行了物理化学表征 (设置时间,防洗,可注射性,强度,无氧化物形成,密封).
- 研究了水化机制,并评估了从人体脱皮叶状牙 (SHED) 中的干细胞的细胞相容性和分化.
主要成果:
- HPMC改善了抗洗和注射能力,但减缓了水合.
- 通过更快的水合,β-TCP/MCPA增强了防洗效果,并减少了定时间.
- 这种水泥具有很高的注射性 (~90%) 和压力强度,具有最佳的比率.
- 经过证明的酸盐沉积,边缘密封性紧密,良好的生物相容性,并促进了SHED骨质/口腔产生的差异化.
结论:
- 开发的TCS/β-TCP/MCPA水泥比传统的TCS材料具有更好的性能.
- 它显示了作为注射可用的生物活性水泥,用于内应用的承诺.
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