系统性免疫炎症指数和系统性炎症反应指数与牙周炎有关:来自NHANES 2009年至2014年的证据
Zhengyun Ren1, Yan Xue2, Hui Zhang2
1Department of General Surgery, Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
International dental journal
|April 30, 2024
概括
系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 的升高与牙周炎的更高患病率有关. 这些发现表明系统性炎症和牙疾病之间存在联系.
科学领域:
- 口腔健康和免疫学
- 系统性炎症生物标志物 系统性炎症生物标志物
背景情况:
- 牙周炎是一种流行的炎症性口腔疾病,严重影响生活质量.
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 是系统性炎症的新兴生物标志物.
研究的目的:
- 研究SII和SIRI水平与牙周炎患病率之间的关联.
- 探索这些炎症指数和牙周炎之间的潜在非线性关系.
主要方法:
- 来自2009-2014年国家健康和营养检查调查 (NHANES) 的8666名参与者的分析.
- 权重流行率比较和二元逻辑回归来评估SII,SIRI和牙周炎之间的关联.
- 限制立方线 (RCS) 图表被用来检查非线性关系.
主要成果:
- 在SII (44.87%) 和SIRI (48.41%) 的第四季度 (Q4) 观察到牙周炎的患病率最高.
- 牙周炎的调整几率比率 (OR) 在SII Q4 (1.19) 和SIRI Q4 (1.18-1.19) 显著更高.
- 敏感性分析证实了高SII/SIRI和牙周炎患病率之间的一致和统计学上显著的关联.
结论:
- 高水平的SII和SIRI显著与牙周炎的患病率增加有关.
- 这些发现强调了系统性炎症和牙周炎之间的潜在联系.
- 强调牙周炎患者意识到同时存在的全身炎症状况,如心血管疾病的重要性.
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