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全癌症分析揭示了RAB3B表达与瘤异质性,免疫微环境和多种癌症的预后之间的相关性

Xu-Sheng Liu^1,2,3, Ya-Lan Chen⁴, Yu-Xuan Chen¹

¹Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Hubei, 442000, China.

Scientific reports

|April 30, 2024

概括

RAB3B蛋白是癌症诊断和预后的潜在生物标志物. 它的表达水平与各种癌症的瘤进展,异质性和免疫反应相关,有助于早期检测和治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

RAB3B蛋白对于细胞的运输和分泌至关重要.
增加RAB3B表达与各种癌症恶性瘤有关.
目前对RAB3B在致癌过程中的理解仅限于特定的癌症亚型.

研究的目的:

综合分析RAB3B在癌症发展中的调节作用和分子机制.
探索RAB3B作为各种癌症类型的诊断和预后生物标志物的潜力.

主要方法:

使用TCGA,GTEx,cBioPortal,HPA,UALCAN和组织微阵列进行全癌症分析.
生物信息技术评估RAB3B表达与预后的相关性,瘤异质性,甲基化和免疫微环境.
在瘤组织中对RAB3B表达的免疫组织化学 (IHC) 验证.

主要成果:

升高的RAB3B表达独立预测多种瘤的预后,并显示适度的诊断准确性.
RAB3B突变与瘤突变负担 (TMB),突变基因瘤异质性 (MATH) 和微卫星不稳定性 (MSI) 有显著的相关性.
在癌症中观察到异常的DNA甲基化模式和RAB3B表达,免疫细胞透和免疫评分之间的显著相关性.

结论:

在瘤和正常组织之间,RAB3B的表达有差异,作为癌症诊断和预后的潜在生物标志物.
RAB3B表达与瘤异质性和免疫特征有关.
RAB3B可以作为早期瘤检测的辅助诊断标记物和各种瘤类型的预后生物标记物.

关键词:

诊断诊断诊断诊断诊断免疫系统的透.胰腺癌是一种癌症.预测预后预测预测在RAB3B中,它是AB3B.

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