外围CD3+CD4+T细胞作为甲状腺眼病中疾病活性指标:年龄依赖的意义
Haiyang Zhang1,2, Lianfei Fang1,2, Yumeng Cheng1,2
1Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
在活跃的甲状腺眼病 (TED) 中,外围CD3+CD4+T细胞升高. 这一发现在年轻患者中尤为重要,有助于预测疾病活动.
科学领域:
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼的自身免疫性疾病.
- 周围淋巴细胞子集可能在TED病原和活动中发挥作用.
研究的目的:
- 分析外周淋巴细胞水平和甲状腺眼病活动之间的关联.
- 调查TED活动的潜在预测标记.
主要方法:
- 追溯分析65名活跃的TED患者和46名不活跃的TED患者.
- 边缘淋巴细胞子集的比较和子组分析.
- 对TED活动进行相关性分析和预测模型的开发.
主要成果:
- 活跃的TED患者的CD3+CD4+T细胞水平显著提高 (P=0.010).
- 增加的CD3+CD4+T细胞在女性,年轻患者 (≤50岁),长期疾病持续时间和中度至重症病例中突出.
- CD3+CD4+T细胞与年轻患者TED活动的MRI指标正相关 (P=0.038).
结论:
- 外围CD3+CD4+T细胞与TED疾病活动有关,特别是在50岁以下的患者中.
- 这项研究增强了对T细胞外围特征的理解.
- CD3+CD4+T细胞显示出作为预测TED活动的客观指标的潜力.
相关概念视频
T Cell Activation and Clonal Selection
714
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
714
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K


