相关实验视频
Updated: Jun 27, 2025

07:34
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
Published on: April 11, 2012
19.4K
败血症和败血性休克患者的辅助免疫治疗药物:23个多学科的共识
Massimo Girardis1, Irene Coloretti2, Massimo Antonelli3,4
1Anesthesia and Intensive Care Medicine, Policlinico Di Modena, University of Modena and Reggio Emilia, Modena, Italy. girardis@unimore.it.
Journal of anesthesia, analgesia and critical care
|April 30, 2024
概括
败血症和败血症休克的辅助疗法是常见的,尽管证据有限. 这种共识为不同的患者表型提供了适当使用的专家指导,旨在改善临床实践.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 败血症和败血性休克死亡率仍然很高,尽管对辅助治疗进行了数十年的研究.
- 没有任何试验明确证明了毒症辅助疗法的明显益处.
- 相互矛盾的结果和缺乏证据需要对辅助疗法选择采取结构化的方法.
研究的目的:
- 提供多学科的共识,合理使用针对性辅助疗法治疗败血症和败血性休克.
- 评估最近的研究和特定辅助治疗的潜在临床益处.
- 通过为临床实践提供专家建议来弥补证据上的差距.
主要方法:
- 一个由多学科专家组成的小组确定了关键的临床表型,治疗方法和结果.
- 进行了广泛的系统文献审查.
- 修改后的RAND/UCLA适宜性方法被用于确定每个表型的治疗适宜性.
主要成果:
- 确定了两个不同的临床表型:压倒性休克和免疫.
- 评估了六种辅助治疗:皮质类固醇,血液净化,免疫球蛋白,殖民地刺激因子和特定免疫疗法 (干扰素-,IL7,抗PD1).
- 在关于治疗适当性的25个临床问题中,在70%问题上达成共识协议.
结论:
- 辅助疗法经常用于败血症治疗,通常没有强有力的临床证据.
- 这种专家共识为适当应用这些疗法提供了结构化的指导.
- 这些建议旨在改善败血症和败血症休克患者的临床管理.
相关概念视频
Adrenergic Agonists: Therapeutic Uses
770
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
770
Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
Pneumonia IV: Management
323
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
323
Antimicrobial Proteins
984
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
984

