对重症监护室危险饮酒患者进行简短干预的有效性:一项随机对照试验
Eliisa Nissilä1, Marja Hynninen2, Ville Jalkanen3
1Department of Perioperative and Intensive Care Medicine, Intensive Care Units, Helsinki University Hospital and Helsinki University, Haartmaninkatu 2, PL 340, 00029, Helsinki, Finland. eliisa.nissila@hus.fi.
Critical care (London, England)
|April 30, 2024
概括
这项研究发现,在短期干预 (BI) 和ICU幸存者的通常护理之间,酒精消费没有显著差异. 然而,两组患者中的许多患者在出院后减少了酒精摄入量.
科学领域:
- 关键护理医学 关键护理医学
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
背景情况:
- 建议对危险的酒精使用进行查和短期干预 (BI),以减轻与酒精有关的健康问题.
- 这项研究调查了与常规护理相比,BI在减少重症监护室 (ICU) 幸存者中饮酒的有效性,这些幸存者有危险酒精使用史.
研究的目的:
- 为了比较单次简短干预 (BI) 与常规治疗 (TAU) 在减少ICU幸存者的酒精消耗方面的有效性.
- 为了评估BI对酒精摄入的影响,酒精使用障碍识别测试-消费 (AUDIT-C) 得分,生活质量和死亡率.
主要方法:
- 患有危险酒精使用的成年ICU患者 (AUDIT-C>5女性,>6男性) 被随机分配给接受BI或TAU.
- BI是在ICU出院时或不久之后进行的. 主要结局是6个月和12个月后自我报告的酒精消费.
- 由于疫情期间招募速度缓慢,试验被提前终止,这可能会限制统计能力.
主要成果:
- 234名患者被随机分配 (117名为BI,117名为TAU). 在6个月或12个月后,群体之间没有观察到中位数酒精摄入量的统计学上显著差异.
- 6个月或12个月后,BI和TAU组之间AUDIT-C分数的中位变化也没有显著差异.
- 虽然在统计学上并不显著,但TAU组的患者在6个月和12个月内戒断的比例高于BI组. 没有发现死亡率差异.
结论:
- 这项研究没有足够的力量来确定单一早期BI在减少ICU幸存者的酒精消费的有效性.
- 尽管缺乏统计学意义上的发现,但干预组和对照组的相当一部分患者减少了饮酒量.
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