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在重症儿童中与COVID-19相关的 Delirium:观察性队列研究

Meghan C Gray¹, Chani Traube², Taylor B Sewell¹

¹Division of Pediatric Critical Care & Hospital Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Journal of intensive care medicine

|May 1, 2024

概括

痴呆症在COVID-19的重症儿童中很常见,特别是那些接受侵入性机械通风的人. 专注于发育障碍,并尽量减少风险在通风减少妄想.

科学领域:

儿科重症监护医药儿科重症监护医药
传染性疾病传染性疾病
神经科学是一个神经科学.

背景情况:

痴呆症在重症儿童中没有得到充分的认可.
COVID-19与成年人的妄想有关,但缺乏儿科数据.
儿童多系统炎症综合征 (MIS-C) 涉及过度炎症,可能增加妄想风险.

研究的目的:

在COVID-19的重症儿童中表征妄.
调查与儿科 Delirium 相关的人口,疾病和治疗因素.
为了测试MIS-C与更高的妄想发病率相关的假设.

主要方法:

追溯的,单中心的队列研究.
包括149例患有SARS-CoV-2感染的儿科重症监护室 (PICU) 住院病例 (2020年3月至2023年3月).
根据COVID-19呼吸系统疾病,MIS-C或其他主要原因对患者进行分类;评估 Delirium 发病率和风险因素.

主要成果:

痴呆症发生在43%的患者中;在需要侵入性机械通风 (IMV) 的患者中发生率最高 (56%).
阿片类药物,德克斯梅德托米丁,麻药和二类药物暴露与妄想相关.
多变量分析将妄想与IMV,女性性别和发育障碍联系起来.

结论:

痴呆症在儿科COVID-19患者中普遍存在,尽管比成年人少.
痴呆症减少策略应针对具有发育障碍的儿童.
尽量减少与IMV相关的风险对于预防这种人群中妄想至关重要.

关键词:

在 COVID-19 疫情中,危急的疾病危急的疾病.妄想妄想妄想妄想妄想重症监护病房是重症监护病房.侵袭性机械通风侵入性机械通风儿科儿科儿科

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