在带细分过程中,肌肉重塑和前后背图案
Francesca Jarero1,2, Andrew Baillie1, Nick Riddiford1
1Department of Life Sciences, Natural History Museum, London, UK.
概括
成人带状的细分可能起源于肌肉系统. 由肌肉表达的位置控制基因 (PCG) 模式是前后 (AP) 轴,类似于其他动物.
科学领域:
- 发育生物学是发展生物学.
- 寄生虫学的寄生虫学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 带虫 (平虫) 独立地进化了细分,使与其他动物的比较变得复杂.
- 平虫的前后 (AP) 模式涉及肌肉中的Wnt信号和位置控制基因 (PCG).
- 之前的研究集中在幼虫上;这项研究研究了成年带状虫,特别是Hymenolepis microstoma.
研究的目的:
- 调查成年Hymenolepis微体中的PCG表达.
- 了解部区域在初始细分模式中的作用.
- 探索带状虫细分的起源.
主要方法:
- 在成年Hymenolepis微口腔中分析PCG表达模式.
- 专注于部区域和生长区域.
- 与肌肉和细分相关的Wnt因子表达的映射.
主要成果:
- 成年人的肌肉表现出新的,从部起源的细分元素.
- Wnt因子表达在分段内区域化和AP极化,起源于肌肉细胞.
- 一个Wnt11对应器划分了部 - 斯特罗比拉过渡.
结论:
- 带虫细分可能来自肌肉系统.
- 肌肉PCG表达可能会模拟AP轴,类似于其他动物.
- 这表明身体模式的基因调节网络得到保护.
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