在肝细胞癌中与乳酸代谢相关的差异表达基因的识别和功能分析
Haiyan Li1, Fuchu Qian2,3, Shengjie Bao4
1Department of Laboratory Medicine, Huzhou Maternity and Child HealthCare Hospital, Huzhou, Zhejiang, China.
Frontiers in genetics
|May 1, 2024
概括
这项研究确定了六个关键的乳酸代谢相关基因,这些基因可以预测肝细胞癌 (HCC) 的预后,并与免疫细胞透相关,为HCC治疗提供了潜在的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 肝细胞癌 (HCC) 由于其高发病率和死亡率而构成重大全球卫生挑战.
- 了解HCC背后的分子机制,包括代谢途径,对于开发有效的治疗策略至关重要.
研究的目的:
- 研究HCC中与乳酸代谢相关基因 (LAMRGs) 相关的表达模式,预后意义和免疫细胞透.
- 确定潜在的生物标志物来预测HCC的预后和指导治疗决策.
主要方法:
- 利用癌症基因组图集 (TCGA) 数据库来识别HCC的差异表达基因 (DEG).
- 选了LAMRG和确定了LAMRDEG,随后进行了功能丰富分析 (GO,KEGG,GSEA).
- 使用多变量考克斯回归和LASSO分析构建了一个预后模型,并分析了基因-蛋白相互作用和免疫细胞透.
主要成果:
- 确定了28种LAMRDEG,在与瘤相关的途径中进行丰富.
- 六个关键基因 (SERPINE1,SPP1,CCNB1,CYP2C9,NQO1,LCAT) 被确定与HCC预后有显著关联.
- 这六种基因的表达与HCC患者的免疫细胞透相关.
结论:
- 拉姆德格可以作为HCC预后的潜在预测剂.
- 这些基因可能会影响免疫细胞的透,这表明它们在瘤微环境中的作用.
- 已确定的LAMRDEGs代表了HCC预后和治疗向的有希望的生物标志物.
更多相关视频
相关概念视频
01:58Cell Specific Gene Expression
13.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.6K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K