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黑色科霍什提取物和瑞塞德龙酸联合给药对卵巢切除的老鼠模型骨健康的影响
Amy L Inselman1, Elysia A Masters1, Jalina N Moore1
1Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States.
Frontiers in pharmacology
|May 1, 2024
概括
在卵巢切除的老鼠中,黑提取物没有影响骨矿物密度 (BMD). 它也没有干扰常见的骨质疏松症药物RISEDRONATE的骨保护作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
- 营养保健品 营养保健品
背景情况:
- 黑 cohosh 提取物是一种用于更年期症状和潜在的骨质损失的食补充剂.
- 像RISEDRONATE这样的双酸盐被处方用于预防绝经后妇女的骨质疏松性骨质损失.
- 黑色科霍什和双酸盐对骨健康的相互作用是未知的.
研究的目的:
- 为了研究黑提取物和risedronate之间的药理动力学相互作用.
- 确定这些化合物对更年期老鼠模型骨矿物密度 (BMD) 的影响.
主要方法:
- 经过卵巢切除和假手术的雌性Sprague-Dawley大鼠接受了24周的治疗.
- 治疗包括载体,乙乙二醇,化酸盐,黑提取物或化酸盐和黑提取物的同时使用.
- 骨矿物质密度 (BMD) 用双能X射线吸收计 (DEXA) 在多个时间点测量.
主要成果:
- 高剂量的瑞塞德龙酸盐显著增加了股骨和脊椎的骨质量.
- 单独使用黑提取物对 BMD 没有显著影响.
- 与RISEDRONATE的同时使用导致黑提取物对BMD的影响很小.
结论:
- 在这个实验模型中,黑提取物不会影响BMD.
- 黑色科霍什提取物不会对化酸盐增强骨的作用产生负面影响.
- 这些发现表明,黑色和化酸盐在骨密度方面没有不良相互作用.
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