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定量乙型肝炎核心抗体和定量乙型肝炎表面抗原:用于慢性乙型肝炎管理的新型病毒生物标志物

Wattana Leowattana¹, Pathomthep Leowattana², Tawithep Leowattana³

¹Department of Clinical Tropical Medicine, Mahidol University, Rachatawee 10400, Bangkok, Thailand. wattana.leo@mahidol.ac.th.

World journal of hepatology

|May 1, 2024

概括

对乙型肝炎核心抗体 (qAnti-HBc) 的量化提供了对感染阶段和治疗反应的新见解. 将qAnti-HBc与qHBsAg结合起来,可以增强其对治疗慢性乙型肝炎的预测能力.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

目前的乙型肝炎病毒 (HBV) 监测依赖于生物标志物,对临床结果的预测能力有限.
需要新的生物标志物来准确评估慢性HBV感染的疾病进展和治疗疗效.

研究的目的:

审查定量HBV核心抗体 (qAnti-HBc) 和定量HBV表面抗原 (qHBsAg) 在治疗慢性乙型肝炎的临床效用.
要突出qAnti-HBc的预后价值,特别是当与qHBsAg一起使用时.

主要方法:

对qAnti-HBc和qHBsAg. 的临床应用现有文献的审查.
分析qAnti-HBc水平与HBV感染特征之间的相关性,包括疾病阶段,炎症,纤维化和隐性感染.

主要成果:

qAnti-HBc水平与HBV感染阶段,肝炎,纤维化和隐性HBV感染有很强的相关性.
qAnti-HBc可以预测自发性或治疗诱导的HBeAg/HBsAg血清,治疗后复发,移植后再感染以及与免疫抑制相关的病毒活性.
qAnti-HBc和qHBsAg的组合增强了诊断和预后潜力.

结论:

qAnti-HBc是一种有价值的非侵入性生物标志物,用于评估慢性乙型肝炎.
虽然qAnti-HBc具有显著的临床实用性,但它不是一个独立的诊断工具;建议将其与qHBsAg结合使用.
为了获得广泛的临床采用,需要进一步开发对qAnti-HBc的标准化,定量测试.

关键词:

慢性乙型肝炎的管理小说病毒生物标志物定量性乙型肝炎核心抗体.定量性乙型肝炎表面抗原.

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