强化生活方式干预对脏结果的10年影响
Linda-Marie U Lavenburg1, Douglas E Schaubel2, Ariana M Chao3
1Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Kidney medicine
|May 1, 2024
概括
在2型糖尿病患者中,强化生活方式干预在10年内没有显著改变功能 (eGFR斜率). 然而,对于那些基线估计膜过率 (eGFR) 较低的人来说,它显示出轻微的益处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 关于非手术肥胖治疗后长期脏结果的数据有限.
- 肥胖和2型糖尿病是慢性病的重要危险因素.
研究的目的:
- 研究强化生活方式干预对2型糖尿病患者功能10年的影响.
- 评估估计的淋巴膜过率 (eGFR) 和尿中白蛋白与肌素的比率 (UACR) 随着时间的推移的变化.
主要方法:
- 随机对照的糖尿病健康行动 (Look AHEAD) 试验的后期分析.
- 包括4,901名患有2型糖尿病和BMI≥25 kg/m2的参与者.
- 通过使用线性混合效应模型,将密集的生活方式干预与糖尿病支持和教育 (常规护理) 进行比较.
主要成果:
- 在强化生活方式干预和常规护理组之间,在10年内估计的淋巴细胞过率 (eGFR) 的斜率没有显著差异.
- 两组之间没有观察到平均eGFR,eGFR斜率或尿液中平均白蛋白与肌素比率 (UACR) 的显著差异.
- 基线eGFR水平没有改变干预对eGFR斜率或平均eGFR的影响.
结论:
- 强化生活方式干预并没有改变2型糖尿病和保存功能的参与者在10年内纵向eGFR斜率.
- 在基线eGFR<80mL/min/1.73m2的参与者中观察到纵向平均eGFR的潜在轻微益处.
- 需要进一步的研究来评估密集的生活方式干预措施对已确诊病患者的长期影响.
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