患有耐药性的儿童心脏功能障碍
Watthana Sridech1, Kamonchanok Intamul2, Kwannapas Saengsin2
1Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Frontiers in neurology
|May 1, 2024
概括
患有耐药性 (DRE) 的儿童表现出心脏功能受损,包括心肌压力降低和腹功能障碍. DRE患者的早期心脏评估可以帮助管理潜在的心脏问题并预防心脏突然死亡.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 中突然意外死亡 (SUDEP) 是患者的一个严重问题.
- 在患者中早期发现心脏功能障碍对于及时干预和预防心脏突然死亡至关重要.
- 耐药性 (DRE) 可能与需要调查的潜在心脏异常有关.
研究的目的:
- 评估和比较患有DRE的儿童的心脏功能与健康对照组.
- 用标准心声图 (SE),组织多普勒成像 (TDI) 和心肌应变评估 (MSE) 进行全面的心脏评估.
- 在患有DRE的儿童中识别潜在的心脏功能障碍标志物.
主要方法:
- 包括27名被诊断患有DRE的儿童和27名年龄相匹配的健康儿童.
- 使用SE,TDI和MSE进行心脏功能评估.
- 在DRE患者和对照者之间,对心声学参数进行比较,包括心交的输入速度,早期透气速度 (e') 和心肌性能指数 (MPI).
主要成果:
- 与对照组相比,患有DRE的儿童表现出明显较低的早期心心 E波流入速度 (p < 0.05).
- 在DRE组 (p <0.05) 观察到早期透析速度 (e) 和心肌性能指数 (MPI) 的降低.
- 发现左心室肌动脉应变的统计学上显著差异,与对照组 (-25.5 IQR) 相比,DRE患者的应变降低了 (-21.1 IQR).
结论:
- 患有DRE的儿童表现出左心室扩张功能受损和心肌张力,这表明心肌变形和收缩减少.
- 这些发现凸显了DRE儿童潜在的亚临床心脏功能障碍的可能性.
- 诸如SE,TDI和MSE之类的心脏学评估是早期诊断和治疗DRE儿童心脏功能障碍的宝贵工具.
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