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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
305
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammation01:38

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相关实验视频

Updated: Jun 27, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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过早分娩,是免疫偏差导致的后果,介于高炎症.

Juan Wei1,2, LiYuan Zhang1,2, Heng Xu3

  • 1Department of Obstetrics, Women's Hospital, of Zhejiang University School of Medicine, Hangzhou, 310006, China.

Heliyon
|May 1, 2024
PubMed
概括

自发的早产可能是由于免疫系统的失调引起的,这会影响母亲和胎儿之间的关系. 了解这些免疫变化和阴道微生物组的变化,可以更好地预测早产.

关键词:
免疫系统的偏差.天生的和适应性免疫力.预测性生物标志物 预测性生物标志物过早分娩 过早分娩是什么孕激素 (Progesterone) 是一种激素.阴道微生物组和代谢组.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生殖生物学 生殖生物学
  • 微生物组研究 微生物组研究

背景情况:

  • 过早分娩是一种复杂的疾病,原因不完全理解.
  • 成功怀孕依赖于一个平衡的母胎免疫微环境.
  • 免疫调节失调,特别是异常的免疫过渡,可能是自发早产的基础.

研究的目的:

  • 审查自发早产的免疫学基础.
  • 探索阴道微生物组在免疫媒介过早分娩中的作用.
  • 为了确定早期早产预测的潜在生物标志物.

主要方法:

  • 文献综述,重点关注早产儿的先天性和适应性免疫.
  • 对将阴道微生物组变化与免疫变化和早产相关的研究进行分析.
  • 讨论孕激素的作用及其与早产时免疫细胞的相互作用.

主要成果:

  • 天生和适应性免疫反应在自发早产中起作用.
  • 阴道微生物组失调可以调解免疫变化,导致早产.
  • 在早产儿群体中观察到改变的孕激素和免疫细胞相互作用.

结论:

  • 免疫偏差,包括耐受性不足和过早激活,可能导致不可持续的怀孕和早产.
  • 阴道微生物组及其代谢物显示出作为早产预测标记物的前景.
  • 对免疫病因和生物标志物的进一步研究对于早期预测和干预至关重要.