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Updated: Apr 9, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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免疫效应细胞相关的神经毒性综合征的早期神经学指标

Yasufumi Yorichika1, Shuichiro Neshige1, Taro Edahiro2

  • 1Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, JPN.

Cureus
|May 1, 2024
PubMed
概括

化学抗原受体T细胞 (CAR-T) 治疗可以导致免疫效应细胞相关的神经毒性综合征 (ICANS). 早期检测和认知监测对于在CAR-T治疗后管理ICANS至关重要.

关键词:
卡特-T细胞治疗细胞因子释放综合征 (CRS) 是一种扩散型大B细胞淋巴瘤 (DLBCL)免疫效应细胞相关的神经毒性综合征 (icans)通过MRI进行MRI.

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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