事件中风风险与以IL-18为中心的炎症网络生物标志物复合物相关联
Richard A Martirosian1, Crystal D Wiedner2, Jasmin Sanchez1
1David Geffen School of Medicine, University of California Los Angeles (R.A.M., J.S., K.T.M., K.M., C.T., M.T., D.S.L., J.D.H.).
Stroke
|May 1, 2024
概括
炎症综合评分 (ICS5),包括互白素-18 (IL-18),与弗雷明汉姆后代队列中较高的中风风险和认知衰退有关. 这一发现可能会改善对中风和血管认知障碍的风险评估.
科学领域:
- 心血管研究研究心血管研究
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 大脑小血管疾病与炎症分子网络有关,特别是互白素-18 (IL-18).
- 弗雷明汉子女队列为研究生物标志物与健康结果之间的关联提供了有价值的数据集.
研究的目的:
- 为了验证炎症生物标志物网络与发生中风风险的关联.
- 评估这个网络与认知障碍之间的关系.
- 为了检查与神经成像标记器的大脑小血管疾病的相关性.
主要方法:
- 测量IL-18,GDF-15,sRAGE,MPO和MCP-1的血清水平是在Framingham后代队列 (检查7) 中进行的.
- 通过对这些生物标志物的日志转换Z-分数进行平均,创建了一个炎症复合得分 (ICS5).
- 多变量回归模型分析了ICS5与中风发病率,认知表现和MRI指标的关联.
主要成果:
- ICS5显着与所有原因中风 (HR 1.48) 和缺血性中风 (HR 1.51) 的风险增加有关.
- ICS5及其组件与弗雷明汉中风风险概况得分相关 (β=0.19).
- 在ICS5和全球认知得分 (β=-0.08) 之间发现了显著的反向关联,但与小血管疾病的MRI标志物没有.
结论:
- 循环炎症生物标志物,特别是IL-18,与弗雷明汉姆后代队列中中风风险增加和认知障碍有关.
- 这项研究可能有助于通过将炎症途径与疾病联系起来,开发对中风和血管认知障碍的定量风险评估.
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