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Updated: Jun 27, 2025

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发现有选择性蛋白质分解向的奇米拉降解剂,向PTP1B作为长期低血糖剂

Zunhua Yang1, Yuqi Ying1, Shaobing Cheng2

  • 1College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Journal of medicinal chemistry
|May 1, 2024
PubMed
概括

针对蛋白质分解的嵌合体 (PROTACs) 有效地降解PTP1B,这是2型糖尿病的关键目标. 化合物75显示出强有力的和选择性的PTP1B降解,显示出长效抗糖尿病疗法的前景.

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